Chronic Kidney Disease

Everything You Need to Know about Peripheral Artery Disease

The vascular system is an intricate network of arteries and veins that distribute and replenish oxygen-rich blood throughout the body. One of the most common vascular conditions affecting patients all over the world is Peripheral Artery Disease. This article will touch on this disease, what it is, how it works, the symptoms it may present, and how modern medicine can manage and treat this condition. 

 

What Is PAD?

Peripheral Artery Disease (PAD) is the narrowing of the arteries, commonly in the lower extremities. This leads to a decreased flow of blood to the affected extremities and is often confused for “poor circulation.” PAD is most commonly caused by atherosclerosis, the buildup of fats or plaque on the artery that causes decreased blood flow in the first place.

Symptoms to Watch Out For

PAD disease may be asymptomatic, but it can also show up as leg, ankle, or foot pain, especially when walking—a condition called claudication. This pain can be mild or severe, and it usually dies down with rest. This is because walking requires a stronger blood flow than rest, especially at a higher pace. Claudication may be tricky to pinpoint, as a number of patients have different ways to describe it, such as cramping pain, leg fatigue, pressure, weakness, or aching. 

 

Other PAD disease symptoms include:

  • Decreased pulse in the leg
  • Coldness on the leg, especially farther down 
  • Skin color changes on the affected limbs, becoming paler with time
  • Sores on the limb that won’t heal
  • Hair loss or slower hair growth in the affected limb
  • Erectile dysfunction

Causes and Risk Factors

The main cause of PAD disease, as we’ve discussed, is atherosclerosis. This plaque buildup that leads to lower blood flow is made up of fat, cholesterol, fibrous tissue, and calcium. Atherosclerosis can result from a number of factors—some of them inevitable—that can increase your risk of developing PAD.

Age and family history play a big role. Most patients with PAD in the US are 65 years or older, though the condition can affect anyone at any age. Genetically, a family history of PAD, heart disease, stroke, or blood vessel disease can be an indicator of predisposition, according to the NIH.

 

A few conditions also contribute to PAD development:

  • Diabetes
  • Obesity
  • High blood pressure
  • Unhealthy blood cholesterol or triglycerides 
  • Kidney disease

Lifestyle behaviors can also lead to plaque buildup. Smoking, for example, can damage your blood vessels and increase your cholesterol levels. A lack of physical activity and increased levels of stress also increase the risks. A diet high in saturated fats—like butter, palm and coconut oil, and red meat—can further feed the plaque. Maintaining a healthy lifestyle and reducing habits that increase the risks is the only way to prevent this disease.

 

Treatment and Management

The most common way to treat PAD disease is to address the factors that further increase atherosclerosis, often through a mixture of medication and lifestyle changes. While this may be adequate for certain cases of PAD, as we have discussed throughout this blog, other conditions may increase atherosclerosis because of how they affect blood pressure and vessel structure. In some cases, more comprehensive PAD treatment options are best.

PRINE Vascular, one of our network’s specialties, explores a more multidisciplinary approach to addressing the factors that contribute to PAD. Since atherosclerosis can be increased by conditions like diabetes and kidney disease, PRINE Health doctors can refer their patients to endocrinologists and nephrologists to address these concerns for more extensive treatment.

If you or a loved one experiences any of the symptoms discussed in this article, don’t hesitate to reach out to a PRINE Vascular location near you. 

Achieving Optimal Results with Balloon Angioplasty Maturation for Dialysis Access

For people dealing with kidney disease, having access to dialysis is like a lifeline. Providing dependable and effective vascular access to all is vital as patients move toward needing dialysis. That’s when balloon angioplasty maturation comes in; it is a technique that assists in establishing strong access sites by widening narrowed blood vessels, ultimately enhancing blood flow.

Understanding Dialysis Access

The Kidney Disease Outcomes Quality Initiatives (KDOQI) prescribes using AVFs as the first choice of dialysis access. Interestingly, a study reported that only about 60% of AVFs mature enough for successful dialysis.

The Kidney Disease Outcomes Quality Initiatives (KDOQI) guidelines favor AVFs over other forms of dialysis access due to their lower complication rates and longer patency. However, the reality that not all AVFs mature adequately for successful dialysis underlines a significant gap in treatment efficacy for end-stage renal disease (ESRD) patients. Balloon angioplasty is key in enhancing the effectiveness of dialysis access by tackling the maturation issue head-on.

The Role of Balloon Angioplasty Maturation

Balloon Angioplasty Maturation (BAM) is currently an important tool to manage AVF maturation failures. This procedure basically uses a balloon catheter to dilate sections of the vein that are narrowed or blocked to improve blood flow and facilitate the maturation process.

An article published by the National Center for Biotechnology Information (NCBI) highlights the procedure’s importance. It describes Balloon-Assisted Maturation of arteriovenous fistulas as an innovative approach to address the common issue of maturation failure. This medical advancement helps overcome anatomical hurdles and promotes quicker and more reliable AVF maturation, which is essential for effective dialysis treatment.

The most important benefits of this procedure are:

  • Reduced Waiting Times: By accelerating the maturation process, patients can commence their dialysis sessions sooner, which is crucial for their health and survival.
  • Decreased Complication Rates: Balloon angioplasty maturation helps to avoid the complications associated with poorly functioning or immature fistulas, such as clotting or infection.
  • Improved Fistula Longevity: By optimizing the maturation and function of the AV fistula, patients can be led to better long-term outcomes, reducing the need for further interventions.

Steps to Achieve Optimal Results

The success of Balloon Angioplasty Maturation hinges on several factors, from the precise selection of candidates to the expertise of the medical team performing the procedure. Here are key considerations for achieving optimal results:

  • Patient Selection: Not all patients with immature AV fistulas are suitable candidates for balloon angioplasty maturation. A comprehensive assessment, including imaging studies and vascular mapping, is essential to identify patients who can benefit from this procedure.
  • Timing of Intervention: The timing of the angioplasty is critical. Intervention that’s too early might not allow the natural dilatation of the vein, while intervening too late might lead to irreversible changes, making the fistula unusable. Determining the right moment requires careful monitoring and expertise.
  • Technical Expertise: The procedure demands a high level of skill and experience from the interventional radiologist or nephrologist. It’s essential to master the navigation of vascular anatomy and execute the procedure precisely.
  • Post-Procedure Care: Following balloon angioplasty maturation, meticulous follow-up care is essential. Patients should be educated on monitoring their fistula for signs of complications, and regular check-ups are necessary to ensure the ongoing health and functionality of the access site.
  • Interdisciplinary Approach: Collaboration among nephrologists, interventional radiologists, dialysis nurses, and vascular surgeons is key to a comprehensive care approach. This teamwork ensures all aspects of the patient’s vascular access needs are met, from initial assessment to post-procedure care.

What the Future Holds

As technology advances and our understanding of vascular biology deepens, the potential for refining balloon angioplasty maturation techniques is significant.

Advancements in balloon catheter design, developing drug-coated balloons to prevent restenosis, and using more accurate imaging methods to guide the procedure can enhance outcomes further. To learn more about balloon angioplasty maturation or talk to a professional, contact us here.

 

The Role of Peripheral Arterial Stenting in Combating Peripheral Arterial Disease

Peripheral arterial disease (PAD) is a common and potentially severe vascular condition that derives from atherosclerosis. Basically, it is the accumulation of plaque within the arteries. This condition impacts millions globally every year because it diminishes blood circulation to limbs and organs, resulting in:

  • Discomfort
  • Limited functionality
  • The potential for limb loss 

In recent years, the field has witnessed notable progress in medical technology and procedures, empowering healthcare professionals to effectively combat this ailment, with peripheral arterial stenting emerging as a pivotal intervention.

Understanding the Impact of Peripheral Arterial Disease

PAD occurs when the peripheral arteries, mainly in the legs, become narrowed or blocked by fatty deposits. Symptoms might include leg pain while walking, numbness, or the development of sores that do not heal. If left untreated, PAD can lead to critical limb ischemia, gangrene, and ultimately amputation.

According to a study published in the Journal of the American Heart Association, the prevalence of PAD in the United States is about 6.8 million among adults 40 years or older. The number escalates with age and is more common among those who have diabetes or smoke.

The Warning Signs of Peripheral Arterial Disease

Typically, one of the first and most common symptoms of PAD is leg pain while walking, a condition known as “intermittent claudication.” Individuals with PAD might observe that they can only walk a particular distance or for a certain amount of time before they begin to experience this cramping or discomfort, often in their calves.

Symptoms may vary and can include additional signs besides leg pain. Some people may even feel numbness or weakness in their legs, which can cause concern. Coldness in one leg compared to the other may also indicate PAD due to decreased blood flow. Sores on the toes, feet, or legs that don’t heal or take an unusually long time to heal are another symptom of PAD. In severe cases, these can progress to critical limb ischemia, a severe form of PAD causing ulcers or gangrene. Lastly, in males, erectile dysfunction may also be a sign of PAD.

However, some persons might not exhibit marked symptoms but could still have PAD, making early detection tricky, underlining the significance of regular PAD screening—especially if you have key risk factors like smoking and diabetes.

Stenting as a Solution for Peripheral Arterial Disease

For moderate to severe cases, one of the leading treatment options is peripheral arterial stenting. Stents, which are small mesh tubes, are placed in the artery to provide structural support from within. Peripheral arterial stenting is minimally invasive and is performed using a catheter threaded through the blood vessels to the site of the blockage.

Numbers that Speak

In a retrospective analysis conducted at a cardiovascular center, researchers delved into the recurrence patterns in 88 patients battling peripheral artery disease (PAD) in the lower limbs following their angioplasty and stenting treatments. They meticulously searched for links between PAD’s return and a host of factors unique to each patient: their backgrounds, whether they smoked, and if they had conditions like diabetes, high blood pressure, or abnormal cholesterol levels.

They found a recurrence, or restenosis, occurring in only 12.5% of cases, pointing to the significant role the chosen revascularization methods and the characteristics of the affected blood vessels play in the likelihood of PAD returning. Curiously, they noted that age, gender, the extent of the artery blockage, and other health issues like smoking, high blood pressure, and cholesterol levels didn’t markedly sway restenosis rates. These findings underscore the advantages of stenting over alternative methods in managing PAD, as it offers a minimally invasive approach with comparable or superior outcomes in preventing recurrence.

The Advantages of Peripheral Arterial Stenting

  • Minimally Invasive: Compared to open surgical methods, stenting is less invasive, reducing risks and recovery time.
  • High Success Rate: Stents provide immediate relief of symptoms and have high success rates in the long term.
  • Low Complication Risks: Complications are rare and typically minor if they do occur.
  • Improved Quality of Life: Patients experience a significant improvement in quality of life with increased mobility and decreased pain.

The Importance of Patient Education When It Comes to Peripheral Arterial Stenting

When it comes to peripheral arterial stenting, ensuring patients are in the know is key to getting the best results. That means laying out all the details about the procedure, what risks and benefits to expect, how to take care of yourself afterward, and any lifestyle changes that might help. Patients need to have a clear picture so they know what to expect and can stick to their doctor’s advice. 

Whether it’s staying on top of meds, keeping up with follow-up appointments, or tweaking their habits like quitting smoking or adjusting their diet, every bit helps for long-term success. Plus, when patients are well-informed, they can have more of a say in their treatment, working closely with their healthcare team to tailor their plans to fit them just right. So, educating patients is really the foundation for good outcomes and better care overall when it comes to peripheral arterial stenting.

In summary, peripheral arterial stenting provides a ray of hope for individuals facing PAD. By remaining well-informed, actively engaging in treatment protocols, and embracing necessary lifestyle adjustments, patients can significantly enhance their prospects for improved health and outcomes. To learn more or schedule a consultation with our professionals, contact us here

Unveiling The Vessels: A Comprehensive Look At Vascular Health For Kidney Patients

Understanding the connection between the heart and the kidneys is simple enough, but we commonly forget that when one of them is in trouble, the other one usually is as well—or is close behind. Fortunately, this is true in the inverse as well: Taking care of your heart is taking care of your kidneys. This article explores the connection between these two vital organs and describes a few ways that you can take care of your vascular system if you struggle with kidney disease.

 

Connecting The Cardiovascular System

The heart pumps blood throughout the body, the lungs oxygenate it, and the kidneys—connected to the vena cava and aorta—clean it up of toxins and waste before they throw it back into the veins and arteries. We then expel the waste and toxins in urine. By controlling sodium and water balance, the kidneys help the heart regulate blood pressure. Of course, blood pressure is a more complicated matter than that, but it is clear that kidneys are crucial. Finally, kidneys also regulate electrolyte balance, some of which are essential for the myocardium—namely potassium, sodium, magnesium, and calcium.

Cardiovascular disease, which is usually present in chronic kidney disease, is a leading cause of mortality in CKD, especially in its end stages. This is all the more reason to make sure we protect the heart as we protect the kidneys.

 

Caring For Vascular And Kidney Health: Detection

The first step to ensure proper health for both systems is detection. Of course, this may seem reductionist, but it truly is the best way to get ahead—and there is more to do. This is especially important for patients with diabetes, as it poses the primary risk for kidney disease. Nephrologists insist that a yearly blood test screening for glomerular filtration rate and a urine test looking for protein in urine are excellent ways to find any issues in your kidneys, as well as keeping an eye on your vascular well-being.

On the subject of proteins, the human body has a steady supply of proteins, like ferritin and elastin. Among these is albumin, a protein produced by the liver that is responsible for binding and transporting substances like hormones, vitamins, enzymes, and drugs throughout the bloodstream. It also keeps fluid from leaking from your blood vessels. Albumin is also the first substance to leak through to your urine when the kidney’s glomeruli start to fail. Consult your nephrologist if you present one of the following symptoms, as it may be an indicator of proteinuria:

  • Foamy urine
  • Frequent urination
  • Swelling

What’s more, detection can help in finding the source of any issues you may present, allowing you and your doctor to make more informed decisions for your treatment.

 

Vascular And Renal Care: Practices

Kidney health starts with water—the clear, simple H2O compound without any additives. Water makes up most of our cellular structure. Constant hydration helps blood vessels work better, including those in the kidneys. It also allows your heart to pump more blood, and it helps oxygen reach your muscles. In the kidneys, it helps prevent stone-forming crystals and lets you produce more urine to expel more waste. Additionally, experts suggest a few more practices to keep both organs healthy.

Diet is also important. It is essential to keep a close eye on cholesterol and triglyceride levels. These two substances can influence the way that kidney and heart conditions evolve. Experts also suggest reducing salts, simple sugars—as you’d find in soda and candy—and saturated fats. In moderation, these substances should be no issue, but cutting them down while struggling with kidney problems is giving your kidneys a step up in their recovery. While we’re on the subject of intake, doctors also suggest reducing ibuprofen and other non-steroidal agents, as kidneys have no way to deal with them.

Activity and weight control are another priority. Physical activity is linked to overall physical health, and it is proven to impact patients with kidney disease positively. Of course, it is vital to stay hydrated and follow your doctor’s guidelines for exercising. Escalations in body weight pose an increased risk of high blood pressure and diabetes, both of which exacerbate kidney disease. It also forces the kidneys to work overtime, filtering more waste than usual, which can increase the risk of disease. We encourage you to approach your nutritionist to explore the best solutions for you.

PRINE Health provides a multidisciplinary approach to kidney health. We pair nephrologists with other professionals to empower patients with kidney disease to live better, fuller lives. Discover the many ways PRINE Vascular can help you, as well as our other specialties.

Addressing Peripheral Vascular Issues For Kidney Patients

 

As a healthcare provider specializing in kidney care, PRINE Health is deeply invested in maintaining the vascular health of our patients. One of the most pressing conditions faced by kidney patients today is peripheral vascular disease (PVD), which affects blood vessels outside the heart and brain and is characterized by narrowed arteries reducing blood flow to the limbs.


 

The Connection Between Peripheral Vascular Disease And Kidney Health

Peripheral vascular disease (PVD) and kidney disease often co-exist in patients due to shared risk factors and common conditions. Atherosclerosis, or the buildup of fatty deposits in artery walls, significantly contributes to PVD. In kidney patients, atherosclerosis can be more prevalent due to their kidney condition, leading to pain during exercise, numbness, and, in severe cases, infection or gangrene.

A factor fueling atherosclerosis in kidney patients is the altered mineral metabolism linked with kidney disease. High blood phosphorus levels, commonly found in advanced kidney disease, can promote calcium and phosphate deposition in arteries, adding to the plaque buildup.

Further, kidney patients frequently battle other conditions like diabetes and high blood pressure, which escalate the risk of developing PVD. Diabetes harms blood vessels throughout the body, encouraging atherosclerosis and increasing the predisposition for PVD. High blood pressure, on the other hand, silently inflicts damage on blood vessels, increasing both kidney disease and PVD risks.

In essence, the strong correlation between PVD and kidney health underscores the need for comprehensive treatment approaches. These approaches must not only tackle kidney disease but also proactively curtail the risk of PVD, underlining that optimal vascular health isn’t optional for kidney patients; it is a medical necessity.


 

The Importance Of Comprehensive Vascular Care For Kidney Patients

For kidney patients enmeshed in the complexity of managing their condition, a proactive and comprehensive approach to care for their vascular health is crucial. At PRINE Health, we acknowledge this imperative, ensuring that preventing and managing peripheral vascular disease (PVD) is a central focus of our provided care.


 

The Cornerstones Of Comprehensive Vascular Care

Our model for comprehensive vascular care revolves around three core pillars—regular vascular screenings, astute medical management, and a range of treatment options encompassing non-invasive and minimally invasive vascular procedures.

  • Vascular Screenings: Regular vascular screenings play a pivotal role in ensuring early detection of PVD. These essential health checks enable us to catch PVD in its infancy, long before it has a chance to progress into a life-threatening condition. Our screening arsenal involves testing procedures that are simple and painless. For example, we often use an ankle-brachial index test, which involves comparing the blood pressure in your ankles to the blood pressure in your arms to ascertain restricted blood flow. Further, ultrasound imaging helps us visualize the blood flow in your limbs—an important diagnostic resource that reveals any pinched or blocked vessels.
  • Medical Management: Aligned with the findings from the vascular screenings, we adopt a medical management approach that is personalized, taking into account the unique health status and needs of every patient. Our medical professionals are ready with a range of strategies, including lifestyle adjustments and medication prescriptions, each aiming to slow down the progression of the disease, manage symptoms, and reduce the risk of complications.
  • Treatment Options: For cases where lifestyle changes and medication aren’t enough, we are equipped with a selection of treatments to confront the disease head-on. Non-invasive treatments range from exercise therapy to advanced wound care and compression therapy. In circumstances where these are not sufficient, we rely on our capability to perform minimally invasive vascular procedures with the utmost precision aimed at restoring proper blood flow.

Every touchpoint within our comprehensive vascular care approach is designed to keep kidney patients one step ahead of PVD. By providing regular assessments, personalized medical management, and appropriate, timely treatments, we are committed to reducing the adverse impacts of PVD on kidney patients’ lives.


 

Benefits Of Vascular Screening

Vascular screening brings numerous benefits to kidney patients:

  • Early Detection: Vascular screenings enable us to detect PVD before it causes significant symptoms. Early detection allows for a wider range of less invasive treatment options and can prevent severe complications.
  • Better Treatment Planning: Regular screenings offer up-to-date information on your vascular health, enabling your healthcare provider to optimize your treatment plan.
  • Reduced Health Risks: Regular vascular screening reduces the risk of severe complications, such as heart attacks, strokes, and limb amputations.

At PRINE Health, we are committed to providing our kidney patients with comprehensive vascular care. Our dedicated team of professionals tailors treatments to individual patient needs, helping them achieve the best possible outcomes. Learn more about our vascular care services here.

 

Do You Know That 1 In 3 CKD Patients May Have Peripheral Vascular Disease?

Peripheral vascular disease (PVD) also known as peripheral arterial disease (PAD) is a slow and progressive disorder characterized by a narrowing, blockage, or spasms in blood vessels in the body. While PVD may affect any blood vessel outside of the heart, the distal extremities (legs and feet) are most commonly affected.

Population data from the National Health and Nutrition Examination Survey (NHANES 1999-2000) reported that 24% of persons with CKD stage 3 or greater (creatinine clearance of <60 mL/min) had peripheral arterial disease as objectively defined by an ankle-brachial index (ABI) <0.9. The use of the ABI as the key diagnostic criteria significantly increased prevalence rates to nearly 35%, especially in more advanced chronic kidney disease.

 

HOW IS PERIPHERAL VASCULAR DISEASE DIAGNOSED?

  • Ankle-brachial index (ABI). An ABI is a comparison of the blood pressure in the ankle with the blood pressure in the arm. To calculate the ABI, the systolic blood pressure (the top number of the blood pressure measurement) of the ankle is divided by the systolic blood pressure of the arm.
  • Doppler ultrasound. This uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs. Your doctor may use the Doppler technique to measure and assess the flow of blood. Faintness or absence of sound may mean blood flow is blocked.
  • Angiogram. This is an X-ray of the arteries and veins to detect blockage or narrowing. This procedure involves inserting a thin, flexible tube into an artery in the leg and injecting a contrast dye. The contrast dye makes the arteries and veins visible on the X-ray.

 

WHAT ARE THE COMPLICATIONS OF PERIPHERAL ARTERIAL DISEASE?

  • Amputation (loss of a limb)
  • Poor wound healing
  • Restricted mobility due to pain or discomfort
  • Severe pain in the affected extremity
  • Stroke (3 times more likely in people with PVD)

 

HOW TO PREVENT PERIPHERAL VASCULAR DISEASE

  • Quit smoking, including avoidance of second-hand smoke and use of any tobacco products
  • Weight loss
  • Limiting or quitting alcohol intake
  • Medicine to reduce your risk for blood clots, as determined by your healthcare provider
  • Exercise 30 minutes or more daily
  • Control of diabetes, cholesterol, and high blood pressure

Once PVD is symptomatic there are more invasive treatments that may be indicated such as angioplasty or vascular surgery.

Due to the high prevalence of PVD in the CKD patient population, PRINE Health is launching PRINE Vascular. We have brought in a skilled interventional radiologist and seasoned Podiatrist. We are starting a sonogram program and will be screening patients in our offices with ABI measurements proactively. A new Vascular lab will be opening in September at Parker Jewish Institute.

Skip The Salt

Facts About Salt And Hypertension In The United States

High blood pressure (also known as hypertension) is associated with three leading causes of death, cardiovascular disease, stroke, and kidney disease. Hypertension is extremely prevalent around the world. About half of adults (45%) with uncontrolled hypertension have a blood pressure of 140/90 mm Hg or higher. This includes 37 million U.S. adults. In 2017, the American College of Cardiology and the American Heart Association published new guidelines for hypertension management and defined high hypertension as blood pressure at or above 130/80 mm Hg. Stage 2 hypertension is defined as blood pressure at or above 140/90 mm Hg.  One notorious contributor to hypertension is excessive dietary salt intake.

Blood Pressure Category Systolic Blood Pressure Diastolic Blood Pressure
  Normal <120 mm Hg and <80 mm Hg
  Elevated 120-129 mm Hg and <80 mm Hg
Hypertension
  Stage 1 130-139 mm Hg or 80-89 mm Hg
  Stage 2 ≥140 mm Hg or ≥90 mm Hg

Salt and Hypertension

Salt is perhaps the most popular flavoring added to food. Unfortunately, there is a downside. Too much salt can lead to fluid retention and worsen hypertension. How much is too much? Well, we need salt. We need about 500 mg per day. Americans consume much, much more than that. We take in on average closer to 3,500 mg, more than 7 times what is necessary. The Dietary Guidelines for Americans by the FDA advise we stick to a diet of fewer than 2,300 mg per day (about one teaspoon).

Salt is ubiquitous and added to all sorts of foods you consume on a daily basis. Moreover, the is often a salt shaker around to add even more. If you already have hypertension you are at risk for extra salt worsening your hypertension. So, when you can help it, skip the salt!  Learn more about High blood pressure.

Book an Appointment